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Nuria Pérez Álvarez

Fundació de Lluita contra la SIDA (FLS) at Hospital Universitari Germans Trias i Pujol

Assistant professor
Statistics and Operations Research Department of Universitat Politècnica de Catalunya


Research Areas

Clinical Trials
Longitudinal data analysis


MSc in Biostatistics, Hasselt Universiteit, November 2006
MSc in Statistics, Universitat Politècnica de Catalunya, July 2005
BA in Statistics, Universitat Politècnica de Catalunya, July 2001

Current Projects:

  • Research Project: ‘Métodos avanzados de análisis de supervivencia en estadística genética’ (MTM2008-06747-C02-01/MTM). Funded by: Ministerio de Educación y Ciencia. Participants: Universitat Politècnica de Catalunya, Universidad de Vic. PI: Guadalupe Gómez Melis. Duration: October 2008-October 2011.
  • Research Project: Consolidate group ‘Modelización Estadístico Multivariante y Computacional’ (2009 SGR 932). Funded by: Generalitat de Catalunya. PI: Carles Cuadras. Duration: 2009-2012.

Selection of Publications:

  • Bonjoch A, Bayés B, Riba J, Puig J, Estany C, Perez-Alvarez N, Clotet B, Negredo E. (2010 Dec.). Validation of estimated renal function measurements compared with the isotopic glomerular filtration rate in an HIVinfected cohort. Antiviral Res. 88(3):347-54.
  • Bonjoch A, Figueras M, Estany C, Perez-Alvarez N, Rosales J, del Rio L, di Gregorio S, Puig J, Gómez G, Clotet B, Negredo E; Osteoporosis Study Group. (2010 Nov). High prevalence of and progression to low bone mineral density in HIV-infected patients: a longitudinal cohort study. AIDS.24(18):2827-33.
  • Aparicio E, Parera M, Franco S, Perez-Alvarez N, Tural C, Clotet B, Martinez MA. (2010 Oct.). IL28B SNP rs8099917 is strongly associated with pegylated interferon-alpha and ribavirin therapy treatment failure in HCV-HIV-1-coinfected patients. Antiviral Therapy 29;15:96.
  • Massanella M, Negredo E, Perez-Alvarez N, Puig J, Ruiz-Hernández R, Bofill M, Clotet B, Blanco J. (2010 Apr). CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART. AIDS. 24;24(7):959-68.
  • Negredo E, Massanella M, Puig J, Perez-Alvarez N,Gallego-Escuredo JM, Villarroya J, Villarroya F, Moltó J, Santos JR, Clotet B, Blanco J. (2010). Nadir CD4 T cell count as predictor and high CD4 T cell intrinsic apoptosis as final mechanism of poor CD4 T cell recovery in virologically suppressed HIV-infected patients: clinical implications. Clin Infect Dis; 50(9): 1300-1308.

Research Areas:

Clinical Trials

Protocol design and sample size calculation

Statistical Analysis and results report


Longitudinal Data

Longitudinal continuous and politomous data analysis

Missing data analysis



Pharmacoeconomic models

Decision models



Universitat Politècnica de Catalunya
Departament d'Estadística i Investigació Operativa